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Article

IgG-Fc glycoengineering in non-mammalian expression hosts

23 May 2012

Abstract excerpt

The remarkable success of therapeutic applications of immunoglobulin G (IgG) in form of monoclonal antibodies and pooled immunoglobulin G preparations has directed attention to this class of glycoproteins. It is commonly appreciated that oligosaccharides attached to the Fc-region play a critical role in the biological activity of IgGs. Thus, glycosylation has been a focus of interest for many scientists and the...

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PMID: 22634260
DOI: 10.1016/j.abb.2012.05.011

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