Article

Tumor Specific Hypoxia-Activated Expression of Cardiac Peptides Using an Engineered Subtype of Escherichia Coli Suppresses Tumor Growth, Angiogenesis and Metastasis in Mouse Model of Breast Cancer

2020-10-06

Abstract excerpt

<title>Abstract</title> <bold>Background</bold>Application of genetically modified non-pathogenic bacteria expressing specific anti-tumor proteins under certain conditions specific to tumors is an effective approach for selective targeting of tumors. We developed here, for the first time, a novel spatiotemporal cancer targeted therapy applying engineered <italic>E. coli</italic> bacteria with capability of exp...

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Literature Corpus work: 277b24e7-a1b9-5de9-a0a3-c245389e79e7
DOI: 10.21203/rs.3.rs-78081/v1

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