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Antibody–Enzyme Fusion Proteins for Cancer Therapy

1 Feb 2011

Abstract excerpt

Advances in biomolecular technology have allowed the development of genetically fused antibody-enzymes. Antibody-enzyme fusion proteins have been used to target tumors for cancer therapy in two ways. In one system, an antibody-enzyme is pretargeted to the tumor followed by administration of an inactive prodrug that is converted to its active form by the pretargeted enzyme. This system has been described as...

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PMID: 21322759
DOI: 10.2217/imt.10.90

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