Article

In vivo Antibody Painting for Next Generation Weight Loss Drugs

2024-08-23

Abstract excerpt

Peptide-based therapeutics are currently in great demand but often suffer from rapid clearance and accumulation in off-target tissues which continue to present barriers in their clinical translation. Here, we developed an electrophilic peptide for the attachment of therapeutics to native immunoglobulin (IgG) in vivo, enabling the bioorthogonal covalent linkage, or ‘painting’, of peptide drugs of choice to circulat...

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Identifiers and source

Literature Corpus work: 78187095-1a24-5d9e-a081-d221c1a03e20
DOI: 10.1101/2024.08.22.609257

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