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Article

Expression, purification, and characterization of a neovasculature targeted rmhTNF-alpha in Escherichia coli.

Protein expression and purification - 1 Jan 2006

Wang Hui, Yan Zhen, Shi Jihong, Han Wei, Zhang Yingqi

Abstract excerpt

The tumor vasculature is a suitable target for cancer treatment. RGD-4C (CDCRGDCFC) peptide can bind to human alphav integrins, which are known to be selectively expressed in human tumor blood vessels. Some studies showed that coupling anticancer drugs or peptides to the RGD peptides yielded compounds with increased efficacy against tumors and lowered toxicity to normal tissues in mice. TNF-alpha mutant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Screening Assays, Antitumor

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Source

Identifiers

PMID: 16027006
DOI: 10.1016/j.pep.2005.05.009

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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