Article
Novel angiogenin mutants with increased cytotoxicity enhance the depletion of pro-inflammatory macrophages and leukemia cells ex vivo.
Cancer immunology, immunotherapy : CII - 1 Dec 2015
Cremer Christian, Braun Hanna, Mladenov Radoslav, Schenke Lea, Cong Xiaojing, Jost Edgar, Brümmendorf Tim H, Fischer Rainer, Carloni Paolo, Barth Stefan, Nachreiner Thomas
Abstract excerpt
Immunotoxins are fusion proteins that combine a targeting component such as an antibody fragment or ligand with a cytotoxic effector component that induces apoptosis in specific cell populations displaying the corresponding antigen or receptor. Human cytolytic fusion proteins (hCFPs) are less immunogenic than conventional immunotoxins because they contain human pro-apoptotic enzymes as effectors. However, one...
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