Article

Vitamin D regulates MerTK-dependent phagocytosis in human myeloid cells

2020-02-07

Abstract excerpt

Vitamin D deficiency is a major environmental risk factor for the development of multiple sclerosis (MS). The major circulating metabolite of vitamin D (25OHD) is converted to the active form (calcitriol) by the hydroxylase enzyme CYP27B1 . In MS lesions the tyrosine kinase MerTK expressed by microglia and macrophages regulates phagocytosis of myelin debris and apoptotic cells that can accumulate and inhibit tiss...

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Literature Corpus work: 81159638-c2f3-587a-b404-d49dad0b1175
DOI: 10.1101/2020.02.06.937482

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