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Article

CD4+CD28- costimulation-independent T cells in multiple sclerosis.

The Journal of clinical investigation - 1 Oct 2001

Markovic-Plese S, Cortese I, Wandinger K P, McFarland H F, Martin R

Abstract excerpt

Multiple lines of evidence suggest that CD4+ lymphocytes initiate autoimmune responses against myelin antigens in multiple sclerosis (MS). The increased frequency of activated myelin-specific cells in MS patients indicates that the activation of autoreactive cells represents a central event in the pathogenesis of the disease. We identified a CD4+ subpopulation that is characterized phenotypically by the...

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Share to CD28 Antigens
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myelin Basic Protein

Share to Receptors, Antigen, T-Cell, gamma-delta

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Source

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Identifiers

PMID: 11602626
DOI: 10.1172/JCI12516
PMCID: PMC209525

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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