Article

Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and CNS remyelination

2015-01-01

Abstract excerpt

Remyelination is a regenerative process that occurs through the formation of myelin sheaths by oligodendrocytes, which are recruited as oligodendrocyte progenitor cells (OPCs) after demyelination in diseases such as Multiple Sclerosis (MS).A key environmental factor regulating OPC differentiation is the fate of myelin debris generated during demyelination. Myelin debris contains inhibitors of OPC differentiation a...

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Literature Corpus work: 287986bc-5a0e-5d60-b169-dd65bab7dd0f
DOI: 10.17863/cam.13950

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