Article
Cladribine inhibits secretion of pro-inflammatory cytokines and phagocytosis in human monocyte-derived M1 macrophages in-vitro.
International immunopharmacology - 1 Feb 2021
Mathiesen Caroline B K, Rudjord-Levann Asha M, Gad Monika, Larsen Jesper, Sellebjerg Finn, Pedersen Anders Elm
Abstract excerpt
Cladribine (Cd) is a purine nucleoside analogue which in an oral formulation is approved for treatment of patients with multiple sclerosis (MS). It is known to mediate the effect through a short-term selective reduction of lymphocytes with minimal effect on the innate immune system. However, a few studies have emerged, that also demonstrate a beneficial immunomodulatory effect of cladribine on monocyte-derived...
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