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Article

Regulatory T cells promote myelin regeneration in the central nervous system

13 Mar 2017

Abstract excerpt

Regeneration of myelin is a dynamic, yet enigmatic process. Dombrowski et al. uncover a central role for regulatory T (Treg) cells in driving oligodendrocyte differentiation, in part via CCN3, a novel factor in Treg function and oligodendrocyte biology. This identifies Treg cells as key cellular players in efficient remyelination. Regeneration of CNS myelin involves differentiation of oligodendrocytes from...

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PMID: 28288125
DOI: 10.1038/nn.4528

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