Article

Threshold concentration and random collision determine the growth of the phase-separated huntingtin inclusion from a stable core

2020-08-06

Abstract excerpt

The processes underlying formation and growth of unfolded protein inclusions are relevant to neurodegenerative diseases. In S. cerevisiae , inclusion bodies formed by mutant huntingtin have characteristics of phase-separated compartments: they are mobile, ovoid, and the contents are diffusible. We have used molecular genetics and quantitative confocal microscopy to probe the relationship between concentration and...

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Identifiers and source

Literature Corpus work: 81100ba5-b09e-5a73-87c6-d6d27c511e9b
DOI: 10.1101/2020.08.05.237073

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