Article
Tracking mutant huntingtin aggregation kinetics in cells reveals three major populations that include an invariant oligomer pool.
The Journal of biological chemistry - 9 Jul 2010
Olshina Maya A, Angley Lauren M, Ramdzan Yasmin M, Tang Jinwei, Bailey Michael F, Hill Andrew F, Hatters Danny M
Abstract excerpt
Huntington disease is caused by expanded polyglutamine sequences in huntingtin, which procures its aggregation into intracellular inclusion bodies (IBs). Aggregate intermediates, such as soluble oligomers, are predicted to be toxic to cells, yet because of a lack of quantitative methods, the kinetics of aggregation in cells remains poorly understood. We used sedimentation velocity analysis to define and compare...
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