Article

Threshold inclusion size triggers conversion of huntingtin to prion-like state that is reversible in newly born cells

2023-02-14

Abstract excerpt

Aggregation of mutant Huntingtin protein (mHtt) leads to neuronal cell death and human disease. We investigated the effect of inclusion formation on yeast cells. Previous work indicates that mHtt protein moves both in and out of inclusions, potentially undergoing refolding in the inclusion. However, the sustained influx of unfolded protein into an inclusion leads to a dramatic change from a phase-separated body to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 34bf381b-870b-5e0e-aca6-d1006f71c18e
DOI: 10.1101/2023.02.13.528394

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Threshold inclusion size triggers conversion of huntingtin to prion-like state that is reversible in newly born cellsDOI 10.1101/2023.02.13.528394Read

Threshold concentration and random collision determine the growth of the phase-separated huntingtin inclusion from a stable coreSemantic proximity Read

Huntingtin Inclusions Trigger Cellular Quiescence, Deactivate Apoptosis, and Lead to Delayed Necrosis.Semantic proximity Read

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death.Semantic proximity Read

ATP modulates self-perpetuating conformational conversion generating structurally distinct yeast prion amyloids that limit autocatalytic amplificationSemantic proximity Read

Yeast as a model to study protein misfolding in aged cellsSemantic proximity Read

Requirement of an intact microtubule cytoskeleton for aggregation and inclusion body formation by a mutant huntingtin fragment.Semantic proximity Read

Conserved features of intermediates in amyloid assembly determine their benign or toxic statesSemantic proximity Read

Soluble oligomers are sufficient for transmission of a yeast prion but do not confer phenotype.Semantic proximity Read

Phase to Phase with TDP-43.Semantic proximity Read

Protein misfolding inside cells: The case of huntingtin and Huntington's diseaseSemantic proximity Read

Spreading of a Prion Domain from Cell-to-Cell by Vesicular Transport in Caenorhabditis elegansSemantic proximity Read

Biological role of bacterial inclusion bodies: a model for amyloid aggregationSemantic proximity Read