Article

Pericytes orchestrate a tumor-restraining microenvironment in glioblastoma

2024-08-27

Abstract excerpt

Glioblastoma (GBM) is characterized by fast progression, an infiltrative growth pattern, and a high rate of relapse. A defining feature of GBM is the existence of spatially and functionally distinct cellular niches, i.e. a hypoxic niche, a leading-edge niche, and a perivascular niche, in which malignant cells engage in paracrine crosstalk with cell types comprising the tumor microenvironment. Here, by analysis of...

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Literature Corpus work: 80f5fd2d-cb60-56fd-9249-917ed4200b8c
DOI: 10.1101/2024.08.26.609765

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