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Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

17 Jul 2025

Abstract excerpt

Glioblastoma (GBM), the most aggressive brain tumor in adults, is characterized by its infiltrative growth along the perivascular space. Mural cells (MCs), encompassing pericytes and smooth muscle cells, are multifunctional perivascular cells implicated in GBM progression. MCs not only facilitate vascular co-option but have also been suggested to contribute to the immunosuppressive tumor microenvironment,...

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PMID: 40674254
DOI: 10.1002/1878-0261.70095

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