Article

Primate-specific adaptation of Ku protects transcriptomic integrity by suppressing Alu-mediated alternative splicing

2025-12-18

Abstract excerpt

Accurate pre-mRNA splicing is essential for the transfer of genetic information but faces unique challenge in higher primates due to the massive expansion of intronic Alu elements 1–3 . While studying Ku, the Ku70/Ku80 heterodimer best known for initiating non-homologous end-joining (NHEJ) by encircling DNA ends 4 , we discovered that Ku expression increased markedly during primate evolution in parallel with Alu...

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Literature Corpus work: 52df00cd-c444-5ec4-96ae-0bc65c44ac9a
DOI: 10.64898/2025.12.17.694518

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