Article

<i>SECISBP2</i> Deficiency Causes a Lethal Perinatal Cardiomyopathy

2026-07-24

Abstract excerpt

<h4>ABSTRACT</h4> Selenoproteins are a specialised group of proteins that incorporate selenium, an essential micronutrient, in the form of selenocysteine. The SECIS binding protein 2 (SBP2), encoded by SECISBP2 , is a crucial component of the selenocysteine incorporation machinery. SECISBP2 deficiency compromises selenoprotein synthesis, and its knockout causes embryonic lethality in mice. Selenium is critical...

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Literature Corpus work: aab857b7-78b4-52b0-8700-c8357ec283fc
DOI: 10.64898/2026.07.22.26358709

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