Article
Distinct biological activity of lipopolysaccharides with different lipid A acylation status from mutant strains of Yersinia pestis and some members of genus Psychrobacter.
Biochemistry. Biokhimiia - 1 Dec 2014
Korneev K V, Kondakova A N, Arbatsky N P, Novototskaya-Vlasova K A, Rivkina E M, Anisimov A P, Kruglov A A, Kuprash D V, Nedospasov S A, Knirel Yu A, Drutskaya M S
Abstract excerpt
Correlation between the chemical structure of lipid A from various Gram-negative bacteria and biological activity of their lipopolysaccharide (LPS) as an agonist of the innate immune receptor Toll-like receptor 4 was investigated. Purified LPS species were quantitatively evaluated by their ability to activate the production of tumor necrosis factor (TNF) by murine bone marrow-derived macrophages in vitro....
Topics
- Acylation
- Animals
- Bone Marrow Cells
- Lipid A
- Macrophages
- Mice
- Mice, Inbred C57BL
- Mutation
- Psychrobacter
- Structure-Activity Relationship