Article
Microbial Lipid A Remodeling Controls Cross-Presentation Efficiency and CD8 T Cell Priming by Modulating Dendritic Cell Function.
Infection and immunity - 19 Jan 2021
Papadopoulos George, Berland Robert, Sunkavalli Ashwini, Coats Stephen R, Darveau Richard P, Genco Caroline A
Abstract excerpt
The majority of Gram-negative bacteria elicit a potent immune response via recognition of lipid A expressed on the outer bacterial membrane by the host immune receptor Toll-like receptor 4 (TLR4). However, some Gram-negative bacteria evade detection by TLR4 or alter the outcome of TLR4 signaling by modification of lipid A species. Although the role of lipid A modifications on host innate immunity has been...
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