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Article

Lack of Lipid A Pyrophosphorylation and Functional <i>lptA</i> Reduces Inflammation by Neisseria Commensals

5 Sept 2012

Abstract excerpt

The interaction of the immune system with Neisseria commensals remains poorly understood. We have previously shown that phosphoethanolamine on the lipid A portion of lipooligosaccharide (LOS) plays an important role in Toll-like receptor 4 (TLR4) signaling. For pathogenic Neisseria, phosphoethanolamine is added to lipid A by the phosphoethanolamine transferase specific for lipid A, which is encoded by lptA. Here,...

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Identifiers

PMID: 22949553
DOI: 10.1128/iai.00506-12

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