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Article

Early evolutionary loss of the lipid A modifying enzyme PagP resulting in innate immune evasion in Yersinia pestis.

Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 2020

Chandler Courtney E, Harberts Erin M, Pelletier Mark R, Thaipisuttikul Iyarit, Jones Jace W, Hajjar Adeline M, Sahl Jason W, Goodlett David R, Pride Aaron C, Rasko David A, Trent M Stephen, Bishop Russell E, Ernst Robert K

Abstract excerpt

Immune evasion through membrane remodeling is a hallmark of Yersinia pestis pathogenesis. Yersinia remodels its membrane during its life cycle as it alternates between mammalian hosts (37 °C) and ambient (21 °C to 26 °C) temperatures of the arthropod transmission vector or external environment. This shift in growth temperature induces changes in number and length of acyl groups on the lipid A portion of...

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Identifiers

PMID: 32868431
DOI: 10.1073/pnas.1917504117
PMCID: PMC7502761

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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