Article
Noncanonical inflammasome activation by intracellular LPS independent of TLR4.
Science (New York, N.Y.) - 13 Sept 2013
Kayagaki Nobuhiko, Wong Michael T, Stowe Irma B, Ramani Sree Ranjani, Gonzalez Lino C, Akashi-Takamura Sachiko, Miyake Kensuke, Zhang Juan, Lee Wyne P, Muszyński Artur, Forsberg Lennart S, Carlson Russell W, Dixit Vishva M
Abstract excerpt
Gram-negative bacteria including Escherichia coli, Citrobacter rodentium, Salmonella typhimurium, and Shigella flexneri are sensed in an ill-defined manner by an intracellular inflammasome complex that activates caspase-11. We show that macrophages loaded with synthetic lipid A, E. coli lipopolysaccharide (LPS), or S. typhimurium LPS activate caspase-11 independently of the LPS receptor Toll-like receptor 4...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.