Article

Potentiating antibiotic treatment using fitness-neutral gene expression perturbations

2019-08-15

Abstract excerpt

The rapid proliferation of multidrug-resistant (MDR) bacteria poses a critical threat to human health, for which new antimicrobial strategies are desperately needed. Here we outline a strategy for combating bacterial infections by administering fitness neutral gene expression perturbations as co-therapies to potentiate antibiotic lethality. We systematically explored the fitness of 270 gene knockout-drug combinati...

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Literature Corpus work: 80c5c7e1-fa7b-5889-ad48-52f6a035ef5f
DOI: 10.1101/736058

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