Article
The impact of aztreonam-clavulanic acid exposure on gene expression and mutant selection using a multidrug-resistant E. coli.
Microbiology spectrum - 4 Mar 2025
Lin Tongtong, Zhang Jiayuan, Diao Shuo, Yan Jinke, Zhang Kexin, Cao Jichao, Huang Junyi, Wang Yaohai, Lv Zhihua, Shen Xiaopeng, Sy Sherwin K B, Lynch Michael, Long Hongan, Yu Mingming
Abstract excerpt
Multidrug-resistant Escherichia coli poses a significant threat to the healthcare system by causing treatment failure in infected patients. The use of a beta-lactam in combination with a beta-lactamase inhibitor has been shown to be an effective strategy to solve this problem. In vitro antimicrobial susceptibility experiments have demonstrated the antimicrobial activity of aztreonam and clavulanate. In this...
Read the complete abstract on PubMedTopics
- Aztreonam
- Escherichia coli
- Drug Resistance, Multiple, Bacterial
- Anti-Bacterial Agents
- Microbial Sensitivity Tests