Article

Genetic ablation of serotonin receptor 2B improves aortic valve hemodynamics in a high-cholesterol diet mouse model

2020-08-18

Abstract excerpt

<h4>ABSTRACT</h4> Calcific aortic valve disease (CAVD) is a deadly disease that is rising in prevalence due to population aging. While the disease is complex and poorly understood, one well-documented driver of valvulopathy is serotonin agonism. Both serotonin overexpression, as seen with carcinoid tumors and drug-related agonism, such as with Fenfluramine use, are linked with various diseases of the valves. Thus...

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Literature Corpus work: 80c32564-05d4-53e9-a574-73e25374d8dd
DOI: 10.1101/2020.08.18.255414

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