Article
Evaluation of links between high-density lipoprotein genetics, functionality, and aortic valve stenosis risk in humans.
Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2014
Arsenault Benoit J, Dubé Marie-Pierre, Brodeur Mathieu R, de Oliveira Moraes Adriana Benjamin, Lavoie Véronique, Kernaleguen Anne-Elen, Guauque-Olarte Sandra, Mathieu Patrick, Pibarot Philippe, Messika-Zeitoun David, Bossé Yohan, Rhainds David, Rhéaume Eric, Tardif Jean-Claude
Abstract excerpt
OBJECTIVE: Studies have shown that high-density lipoprotein (HDL)-raising compounds induce regression of aortic valve stenosis (AVS) in animal models. However, whether patients with AVS have an impaired HDL metabolism is unknown. APPROACH AND RESULTS: A total of 1435 single nucleotide polymorphisms in genes associated with HDL cholesterol levels (in or around GALNT2, LPL, ABCA1, APOA5, SCARB1, LIPC, CETP, LCAT,...
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