Article
Diet-induced aortic valve disease in mice haploinsufficient for the Notch pathway effector RBPJK/CSL.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2011
Nus Meritxell, MacGrogan Donal, Martínez-Poveda Beatriz, Benito Yolanda, Casanova Jesús C, Fernández-Avilés Francisco, Bermejo Javier, de la Pompa José Luis
Abstract excerpt
OBJECTIVE: Calcific aortic valve disease is similar to atherosclerosis in that both diseases result from chronic inflammation and endothelial dysfunction. Heterozygous NOTCH1 mutations have been associated to calcific aortic disease and a bicuspid aortic valve. We investigated whether mice with genetic inactivation of the Notch signaling pathway are prone to develop valve disease when exposed to a predisposing...
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