Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Serotonin 2B receptor is required for heart development

15 Aug 2000

Abstract excerpt

Several lines of evidence suggest that the serotonin (5-hydroxytryptamine, 5-HT) regulates cardiovascular functions during embryogenesis and adulthood. 5-HT binds to numerous cognate receptors to initiate its biological effects. However, none of the 5-HT receptor disruptions in mice have yet resulted in embryonic defects. Here we show that 5-HT(2B) receptor is an important regulator of cardiac development. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Phosphodiesterase function and regulation
Share to Receptor Mechanisms and Signaling
Share to Renin-Angiotensin System Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10944220
DOI: 10.1073/pnas.97.17.9508

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Serotonin 2B receptor is required for heart developmentPMID 10944220Read ↗

[Serotonin and the cardiovascular system: role of the serotoninergic 5-HT 2B receptor].Semantic proximity Read ↗

Ablation of serotonin 5-HT(2B) receptors in mice leads to abnormal cardiac structure and function.Semantic proximity Read ↗

Developmentally regulated serotonin 5‐HT<sub>2B</sub> receptorsSemantic proximity Read ↗

[The 5-HT2B receptor: a main cardio-pulmonary target of serotonin].Semantic proximity Read ↗

Functional Consequence of Serotonin/5-HT 2B Receptor Signaling in HeartSemantic proximity Read ↗

Genetic ablation of serotonin receptor 2B improves aortic valve hemodynamics in a high-cholesterol diet mouse modelSemantic proximity Read ↗

Dilated and failing cardiomyopathy in bradykinin B(2) receptor knockout mice.Semantic proximity Read ↗

Serotonin transporter deficiency in mice results in an increased susceptibility to HTR2B-dependent pro-fibrotic mechanisms in the cardiac valves and left ventricular myocardium.Semantic proximity Read ↗

Cardiac ErbB-1/ErbB-2 mutant expression in young adult mice leads to cardiac dysfunction.Semantic proximity Read ↗

The cardiac ventricular 5-HT4 receptor is functional in late foetal development and is reactivated in heart failure.Semantic proximity Read ↗

Essential Roles of Her2/erbB2 in Cardiac Development and FunctionSemantic proximity Read ↗

Serotonin 2B Receptor Antagonism Prevents Heritable Pulmonary Arterial Hypertension.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.