Article

Culture enhanced MSCs to boost haematopoietic engraftment in a model of the post-leukaemic bone marrow niche

2026-07-30

Abstract excerpt

Relapse remains a leading cause of treatment failure in acute myeloid leukaemia (AML), making haematopoietic stem cell transplantation (HSCT) the only curative option for many patients. Yet HSCT efficacy is often limited by impaired engraftment, driven by AML-induced remodelling of the bone marrow stem cell niche. Mesenchymal stromal cells (MSCs) are key mediators of niche formation and could, in principle, restor...

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Literature Corpus work: 809cafc7-0bb8-5628-bb0b-524e0b1c538e
DOI: 10.64898/2026.07.30.741738

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