Article

NFĸB Targeting in Bone Marrow Mesenchymal Stem Cell-Mediated Support of Age-Linked Hematological Malignancies.

2021-07-09

Abstract excerpt

<title>Abstract</title> <p>Mesenchymal stem cells (MSCs) can become dysfunctional in patients with hematological disorders. An unanswered question is whether age-linked disruption of the bone marrow (BM) microenvironment is secondary to hematological dysfunction or vice versa. We therefore studied MSC function in patients with different hematological disorders and found decreased MHC-II except from one sample wit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5eb5b65e-5d19-56c7-8266-c78ace75d8d9
DOI: 10.21203/rs.3.rs-672889/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

NFĸB Targeting in Bone Marrow Mesenchymal Stem Cell-Mediated Support of Age-Linked Hematological Malignancies.DOI 10.21203/rs.3.rs-672889/v1Read

Aging- and Senescence-associated Changes of Mesenchymal Stromal Cells in Myelodysplastic Syndromes.Semantic proximity Read

Bone Marrow-Derived Mesenchymal Stromal Cells: A Novel Target to Optimize Hematopoietic Stem Cell Transplantation Protocols in Hematological Malignancies and Rare Genetic DisordersSemantic proximity Read

Mesenchymal stem cells: A revolution in therapeutic strategies of age-related diseasesSemantic proximity Read

Allogeneic stem cell transplantation for myelofibrosis in 2012.Semantic proximity Read

Epigenetic therapy targeting bone marrow mesenchymal stem cells for age-related bone diseasesSemantic proximity Read

A Non-Invasive Stem Cell Therapy Boosts Lymphopoiesis and Averts Age-Related Blood Diseases in MiceSemantic proximity Read

Bone marrow-derived mesenchymal stem/stromal cells in patients with acute myeloid leukemia reveal transcriptome alterations and deficiency in cellular vitalitySemantic proximity Read

Secretome of Young Mesenchymal Stromal Cells Rejuvenates Aged Mesenchymal Stromal Cells by Normalizing Their Phenotype and Restoring Their Differentiation Profile.Semantic proximity Read

Alteration Analysis of Bone Marrow Mesenchymal Stromal Cells from De Novo Acute Myeloid Leukemia Patients at Diagnosis.Semantic proximity Read

Mesenchymal stem cell agingSemantic proximity Read

Age-related changes in mesenchymal stem cells identified using a multi-omics approach.Semantic proximity Read

Detailed Characterization of Mesenchymal Stem/Stromal Cells from a Large Cohort of AML Patients Demonstrates a Definitive Link to Treatment OutcomesSemantic proximity Read