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Biomimetic Culture Strategies for the Clinical Expansion of Mesenchymal Stromal Cells.

ACS biomaterials science & engineering - 10 Jul 2023

Wong Kuan Un, Zhang Anyu, Akhavan Behnam, Bilek Marcela M, Yeo Giselle C

Abstract excerpt

Mesenchymal stromal/stem cells (MSCs) typically require significant ex vivo expansion to achieve the high cell numbers required for research and clinical applications. However, conventional MSC culture on planar (2D) plastic surfaces has been shown to induce MSC senescence and decrease cell functionality over long-term proliferation, and usually, it has a high labor requirement, a high usage of reagents, and...

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PMID: 33599471
DOI: 10.1021/acsbiomaterials.0c01538

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