Article

Replication-competent HIV-1 in human alveolar macrophages and monocytes despite nucleotide pools with elevated dUTP

2022-05-04

Abstract excerpt

Although CD4 + memory T cells are considered the primary latent reservoir for HIV-1, replication competent HIV has been detected in tissue macrophages in both animal and human studies. During in vitro HIV infection, the depleted nucleotide pool and high dUTP levels in monocyte derived macrophages (MDM) leads to proviruses with high levels of dUMP, which has been implicated in viral restriction or reduced transcr...

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Literature Corpus work: 80930d9c-7965-5d0e-80b2-3bf5e92b88cb
DOI: 10.1101/2022.05.03.490432

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