Article

Deficient Uracil Base Excision Repair Leads to Persistent dUMP in HIV Proviruses During Infection of Monocytes and Macrophages

2020-01-13

Abstract excerpt

<title>Abstract</title> <p>Background Non-dividing cells of the myeloid lineage such as monocytes and macrophages are target cells of HIV that have low dNTP pool concentrations and elevated levels of dUTP, which leads to frequent incorporation of dUMP opposite to A during reverse transcription (“uracilation”). One factor determining the fate of dUMP in proviral DNA is the host cell uracil base excision repair (UB...

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Literature Corpus work: ac6a0bef-bd59-587a-8da0-d593609559d0
DOI: 10.21203/rs.2.20758/v1

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