Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells.

eLife - 20 Sept 2016

Hansen Erik C, Ransom Monica, Hesselberth Jay R, Hosmane Nina N, Capoferri Adam A, Bruner Katherine M, Pollack Ross A, Zhang Hao, Drummond Michael Bradley, Siliciano Janet M, Siliciano Robert, Stivers James T

Abstract excerpt

We report that a major subpopulation of monocyte-derived macrophages (MDMs) contains high levels of dUTP, which is incorporated into HIV-1 DNA during reverse transcription (U/A pairs), resulting in pre-integration restriction and post-integration mutagenesis. After entering the nucleus, uracilated viral DNA products are degraded by the uracil base excision repair (UBER) machinery with less than 1% of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair
Share to DNA, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Infections

Share to Macrophages

Share to Reverse Transcription

Share to Uracil

Share to Virus Integration

Source

Open in PubMed Open full text

Identifiers

PMID: 27644592
DOI: 10.7554/eLife.18447
PMCID: PMC5030084

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells.PMID 27644592Read ↗

Deficient uracil base excision repair leads to persistent dUMP in HIV proviruses during infection of monocytes and macrophagesSemantic proximity Read ↗

Deficient Uracil Base Excision Repair Leads to Persistent dUMP in HIV Proviruses During Infection of Monocytes and MacrophagesSemantic proximity Read ↗

Replication-competent HIV-1 in human alveolar macrophages and monocytes despite nucleotide pools with elevated dUTPSemantic proximity Read ↗

HIV DNA is heavily uracilated, which protects it from autointegration.Semantic proximity Read ↗

The Complex Interactions Between HIV-1 and Human Host Cell Genome: From Molecular Mechanisms to Clinical PracticeSemantic proximity Read ↗

Uracil DNA glycosylase initiates degradation of HIV-1 cDNA containing misincorporated dUTP and prevents viral integration.Semantic proximity Read ↗

Distribution and fate of HIV-1 unintegrated DNA species: a comprehensive updateSemantic proximity Read ↗

DNA damage repair machinery and HIV escape from innate immune sensingSemantic proximity Read ↗

Human macrophages support persistent transcription from unintegrated HIV-1 DNASemantic proximity Read ↗

Detailed Characterization of Early HIV-1 Replication Dynamics in Primary Human MacrophagesSemantic proximity Read ↗

Tight Interplay among SAMHD1 Protein Level, Cellular dNTP Levels, and HIV-1 Proviral DNA Synthesis Kinetics in Human Primary Monocyte-derived MacrophagesSemantic proximity Read ↗

Leishmania Induces Survival, Proliferation and Elevated Cellular dNTP Levels in Human Monocytes Promoting Acceleration of HIV Co-InfectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.