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Article

Uracil DNA glycosylase initiates degradation of HIV-1 cDNA containing misincorporated dUTP and prevents viral integration.

Proceedings of the National Academy of Sciences of the United States of America - 5 Feb 2013

Weil Amy F, Ghosh Devlina, Zhou Yan, Seiple Lauren, McMahon Moira A, Spivak Adam M, Siliciano Robert F, Stivers James T

Abstract excerpt

HIV-1 reverse transcriptase discriminates poorly between dUTP and dTTP, and accordingly, viral DNA products become heavily uracilated when viruses infect host cells that contain high ratios of dUTP:dTTP. Uracilation of invading retroviral DNA is thought to be an innate immunity barrier to retroviral infection, but the mechanistic features of this immune pathway and the cellular fate of uracilated retroviral DNA...

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Identifiers

PMID: 23341616
DOI: 10.1073/pnas.1219702110
PMCID: PMC3568341

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