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Detailed Characterization of Early HIV-1 Replication Dynamics in Primary Human Macrophages

10 Nov 2018

Abstract excerpt

Macrophages are natural target cells of human immunodeficiency virus type 1 (HIV-1). Viral replication appears to be delayed in these cells compared to lymphocytes; however, little is known about the kinetics of early post-entry events. Time-of-addition experiments using several HIV-1 inhibitors and the detection of reverse transcriptase (RT) products with droplet digital PCR (ddPCR) revealed that early...

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PMID: 30423802
DOI: 10.3390/v10110620

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