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Quantitative trait locus mapping identifies <i>Col4a6</i> as a novel regulator of striatal dopamine level and axonal branching in mice

2020-06-28

Abstract excerpt

The features of dopaminergic neurons (DAns) of nigrostriatal circuitry are orchestrated by a multitude of yet unknown factors, many of them genetic. Genetic variation between individuals at baseline can lead to differential susceptibility to and severity of diseases. As decline of DAns, a characteristic of Parkinson’s disease, heralds a significant decrease in dopamine level, measuring dopamine can reflect the int...

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Literature Corpus work
80925f2d-0e8a-5e51-a2de-abe010068529
DOI
10.1101/2020.06.28.176206
Open publication

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Quantitative trait locus mapping identifies <i>Col4a6</i> as a novel regulator of striatal dopamine level and axonal branching in miceDOI 10.1101/2020.06.28.176206
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