Article
Genetic Modifiers of Pathogenic LRRK2 G2019S Neurodegeneration in <i>Drosophila</i>
2018-05-30
Abstract excerpt
Disease phenotypes can be highly variable among individuals with the same pathogenic mutation. There is increasing evidence that background genetic variation is a strong driver of disease variability in addition to the influence of environment. To understand the genotype-phenotype relationship that determines the expressivity of a pathogenic mutation, a large number of backgrounds must be studied. This can be effi...
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Identifiers and source
- Literature Corpus work
- 6055f3fb-2be2-599a-bc41-f53f540fcb10
- DOI
- 10.1101/331991