Article
Genetic Modifiers of Neurodegeneration in a Drosophila Model of Parkinson's Disease.
Genetics - 1 Aug 2018
Lavoy Sierra, Chittoor-Vinod Vinita G, Chow Clement Y, Martin Ian
Abstract excerpt
Disease phenotypes can be highly variable among individuals with the same pathogenic mutation. There is increasing evidence that background genetic variation is a strong driver of disease variability in addition to the influence of environment. To understand the genotype-phenotype relationship that determines the expressivity of a pathogenic mutation, a large number of backgrounds must be studied. This can be...
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