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Article

Dissecting 16p11.2 hemi-deletion to study sex-specific striatal phenotypes of neurodevelopmental disorders.

Molecular psychiatry - 1 May 2024

Kim Jaekyoon, Vanrobaeys Yann, Kelvington Benjamin, Peterson Zeru, Baldwin Emily, Gaine Marie E, Nickl-Jockschat Thomas, Abel Ted

Abstract excerpt

Neurodevelopmental disorders (NDDs) are polygenic in nature and copy number variants (CNVs) are ideal candidates to study the nature of this polygenic risk. The disruption of striatal circuits is considered a central mechanism in NDDs. The 16p11.2 hemi-deletion (16p11.2 del/+) is one of the most common CNVs associated with NDD, and 16p11.2 del/+ mice show sex-specific striatum-related behavioral phenotypes....

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Identifiers

PMID: 38278994
DOI: 10.1038/s41380-024-02411-0
PMCID: PMC11189748

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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