A humanized ossicle model of myelofibrosis reveals THPO-driven fibrosis, osteosclerosis and SPP1-dependent microenvironmental remodeling

Abstract excerpt

Myelofibrosis (MF) is the most severe myeloproliferative neoplasm. Current therapies – except for allogeneic stem cell transplantation – are largely supportive which highlights the need for improved disease models and novel therapeutic targets. Here, we established a humanized MF model by transplanting thrombopoietin (THPO)-overexpressing human bone marrow CD34□ cells into humanized bone marrow ossicles generated...

Topics

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• Acute Myeloid Leukemia Research
• Extracellular Matrix
• Gene Expression Regulation
• Kruppel-like factors research
• Mutation
• Myeloproliferative Neoplasms: Diagnosis and Treatment
• Myofibroblasts
• Primary Myelofibrosis

Identifiers and source

Literature Corpus work

808e73dd-64b7-55a5-973e-4fca864a5646

DOI

10.64898/2026.03.12.711163