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Article

Pathogenesis of myelofibrosis with myeloid metaplasia.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Nov 2005

Tefferi Ayalew

Abstract excerpt

The primary disease process in myelofibrosis with myeloid metaplasia (MMM) is clonal myeloproliferation with varying degrees of phenotypic differentiation. This is characteristically accompanied by secondary intramedullary collagen fibrosis, osteosclerosis, angiogenesis, and extramedullary hematopoiesis. Modern clonality studies have confirmed the multipotent stem-cell origin of the neoplastic process in MMM. The...

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Share to Bone Marrow
Share to Cytokines
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to JAK2 gene

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Source

Identifiers

PMID: 16293880
DOI: 10.1200/JCO.2004.00.9316

Genes

JAK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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