Article
Metabolic basis for the differential susceptibility of Gram-positive pathogens to fatty acid synthesis inhibitors.
Proceedings of the National Academy of Sciences of the United States of America - 13 Sept 2011
Parsons Joshua B, Frank Matthew W, Subramanian Chitra, Saenkham Panatda, Rock Charles O
Abstract excerpt
The rationale for the pursuit of bacterial type 2 fatty acid synthesis (FASII) as a target for antibacterial drug discovery in Gram-positive organisms is being debated vigorously based on their ability to incorporate extracellular fatty acids. The regulation of FASII by extracellular fatty acids was examined in Staphylococcus aureus and Streptococcus pneumoniae, representing two important groups of pathogens....
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