Article

Chemogenomic profiling of anti-leishmanial efficacy and resistance in the related kinetoplastid parasite <i>Trypanosoma brucei</i>

2019-04-11

Abstract excerpt

The arsenal of drugs used to treat leishmaniasis, caused by Leishmania spp., is limited and beset by toxicity and emergent resistance. Furthermore, our understanding of drug mode-of-action and potential routes to resistance is limited. Forward genetic approaches have revolutionised our understanding of drug mode-of-action in the related kinetoplastid parasite, Trypanosoma brucei . Therefore, we screened our geno...

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Literature Corpus work: af46cbd7-0a7b-57e1-8447-0c889c1c801c
DOI: 10.1101/605873

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