Article

Somatic and germline mutational processes across the tree of life

2025-12-30

Abstract excerpt

The characterisation of mutational processes active in somatic and germline cells in vivo has predominantly focused on human cancers1,2, normal tissues3-5 and model organisms6-8. Beyond mammals9, little is known about mutational processes across the tree of life. We developed himut (high-fidelity mutation), an algorithm to identify somatic mutations from circular consensus long-read sequencing data, deploying it o...

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Literature Corpus work: 80510fe6-d240-52d3-9dce-e3fb6a587691
DOI: 10.64898/2025.12.28.691837

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