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The Discovery of Mutated Driver Pathways in Cancer: Models and Algorithms.

IEEE/ACM transactions on computational biology and bioinformatics - 1 Jan 2000

Zhang Junhua, Zhang Shihua

Abstract excerpt

The pathogenesis of cancer in human is still poorly understood. With the rapid development of high-throughput sequencing technologies, huge volumes of cancer genomics data have been generated. Deciphering that data poses great opportunities and challenges to computational biologists. One of such key challenges is to distinguish driver mutations, genes as well as pathways from passenger ones. Mutual exclusivity of...

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PMID: 28113329
DOI: 10.1109/TCBB.2016.2640963

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