Article

HLA-E-VL9 antibodies enhance NK cell and CD8 <sup>+</sup> T cell cytotoxicity against HIV-infected CD4 <sup>+</sup> T cells

2024-07-11

Abstract excerpt

<h4>SUMMARY</h4> A major natural killer (NK) cell and CD8 + T cell checkpoint is mediated by the inhibitory receptor NKG2A/CD94 and its ligand, HLA-E complexed with 9 amino acid HLA-Ia leader sequence-derived peptides termed VL9 (HLA-E-VL9). Here, we used structure-based design and high throughput library screening to generate antibodies that block NKG2A/CD94 interactions, resulting in direct NK and CD8 + T cel...

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Literature Corpus work: 8034112f-966b-5e63-a0d9-384e141a60de
DOI: 10.1101/2024.07.08.602401

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HLA-E-VL9 antibodies enhance NK cell and CD8 <sup>+</sup> T cell cytotoxicity against HIV-infected CD4 <sup>+</sup> T cellsDOI 10.1101/2024.07.08.602401Read

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