Article

Impairing NK-mediated immune rejection through NKG2DL editing to improve CAR-T cell persistence

2026-04-09

Abstract excerpt

CAR-T immunotherapy has achieved remarkable efficacy in hematologic malignancies. However, the widespread clinical adoption of autologous CAR‑T products remains constrained by high costs, lengthy manufacturing process, and limited accessibility. Universal or off the shelf CAR-T (UCAR-T) cells derived from healthy donors offer a promising alternative, enabling immediate treatment at a lower cost. However, the allog...

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Literature Corpus work: 9270f7ba-1ed5-5c32-8042-458f0a3d56d0
DOI: 10.64898/2026.04.07.716907

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