Article

Engineering NKG2D ligand affinity transforms EGFR-targeted NK cell engagers into high-potency effectors against pancreatic cancer

2026-01-20

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Pancreatic ductal adenocarcinoma (PDAC) often escapes T cell–mediated immunity through impaired major histocompatibility complex class I (MHC-I) antigen presentation, rendering it largely refractory to current immunotherapies. Because natural killer (NK) cells are capable of eliminating MHC-I–low tumor cells, redirecting NK cytotoxicity represents a promising...

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Literature Corpus work: 0b9c134a-172b-51c6-a391-72e1788ca23b
DOI: 10.21203/rs.3.rs-8589580/v1

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